Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 391065, 6 pages
Research Article

Hypolipidemic Activity and Antiatherosclerotic Effect of Polysaccharide of Polygonatum sibiricum in Rabbit Model and Related Cellular Mechanisms

1School of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China
2Department of Laboratory Medicine, Guiyang Medical College, Guiyang, Guizhou 550004, China
3Department of Cardiology, Fuzhou City First People’s Hospital, Fuzhou, Jiangxi 344000, China
4Department of Urology, Ningbo Zhenhai People's Hospital, Ningbo, Zhejiang 315202, China
5Chongqing Institute for Food and Drug Control, Chongqing Engineering Center for Pharmaceutical Process and Quality Control, China

Received 28 June 2014; Revised 11 August 2014; Accepted 19 August 2014

Academic Editor: Qunhao Zhang

Copyright © 2015 Jun-xuan Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Y. Chang, “Polygonatum sibiricum Red.Anti-aging regimen and facial make-up role in interpreting,” Chinese Archives of Traditional Chinese Medicine, vol. 29, no. 3, pp. 593–594, 2011 (Chinese). View at Google Scholar
  2. T. Debnath, S. R. Park, D. H. Kim, J. E. Jo, and B. O. Lim, “Antioxidant and anti-inflammatory activity of Polygonatum sibiricum rhizome extracts,” Asian Pacific Journal of Tropical Disease, vol. 3, no. 4, pp. 308–313, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. S.-R. Wu, Y.-Y. Li, and X. Wu, “Effect of polygona-polysaccharose on atheromatous plaque: experiment with rabbits,” National Medical Journal of China, vol. 88, no. 2, pp. 127–130, 2008. View at Google Scholar · View at Scopus
  4. P. Zhang, D. Liu, and Y. Y. Li, “The influence of Polygonatum sibiricum polysaccharides on the expressing of IL-6 and CRP in atherosclerotic rabbits,” Journal of Clinical Research, vol. 23, no. 7, pp. 1100–1101, 2006. View at Google Scholar
  5. J. Balkan, O. Kanbağli, A. Hatipoğlu et al., “Improving effect of dietary taurine supplementation on the oxidative stress and lipid levels in the plasma, liver and aorta of rabbits fed on a high-cholesterol diet,” Bioscience, Biotechnology, and Biochemistry, vol. 66, no. 8, pp. 1755–1758, 2002. View at Google Scholar
  6. T. Wakabayashi, H. Naito, K. Takara et al., “Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration,” Investigative Ophthalmology & Visual Science, vol. 54, no. 10, pp. 6686–6693, 2013. View at Publisher · View at Google Scholar
  7. M. Artwohl, A. Lindenmair, M. Roden et al., “Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure,” Atherosclerosis, vol. 202, no. 2, pp. 351–362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. B. G. Ilagan and B. G. Amsden, “Surface modifications of photocrosslinked biodegradable elastomers and their influence on smooth muscle cell adhesion and proliferation,” Acta Biomaterialia, vol. 5, no. 7, pp. 2429–2440, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Chaulet, C. Desgranges, M.-A. Renault et al., “Extracellular nucleotides induce arterial smooth muscle cell migration via osteopontin,” Circulation Research, vol. 89, no. 9, pp. 772–778, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Chen and S. H. Yan, “The protection effect of Polygonatum sibiricum polysaccharides on H2O2-induced vascular endothelial cell injury,” Lishizhen Medicine and Materia Medica Research, vol. 22, no. 3, pp. 623–624, 2011 (Chinese). View at Google Scholar
  11. W. P. Ni, X. X. Zhu, H. D. Wang, Q. Y. Li, and M. Wan, “Research of polygonatum polysaccharide on the protective mechanism of LPS-induced HUVEC injury,” Chinese Archives of Traditional Chinese Medicine, vol. 30, no. 12, pp. 2644–2646, 2012 (Chinese). View at Google Scholar
  12. T. H. Lee, J. Chang, and B. M. Kim, “Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells,” Biochemical and Biophysical Research Communications, vol. 445, no. 3, pp. 615–621, 2014. View at Google Scholar
  13. J. F. Li, S. Chen, J. D. Feng, M. Y. Zhang, and X. X. Liu, “Probucol via inhibition of NHE1 attenuates LPS-accelerated atherosclerosis and promotes plaque instability in vivo,” Experimental and Molecular Pathology, 2014. View at Google Scholar
  14. X. Zhang, G. Borjihan, and N. Zhaorigetu, “Determination of relative molecular mass and composition for Polygonatum sibiricum polysaccharide by high performance liquid chromatography,” Chinese Journal of Chromatography, vol. 23, no. 4, pp. 394–396, 2005 (Chinese). View at Google Scholar · View at Scopus