Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice

Table 1

Effects of experimental diets and K21 administration on mice.

Parameters assessed	ND	HFD	HFD + K21
Initial body weight (g)	22.56 ± 1.46	22.51 ± 1.30	22.61 ± 1.79
Final body weight (g)	24.00 ± 1.2	26.66 ± 1.74^**	24.80 ± 1.8
Food intake (g/mouse/day)	2.72 ± 0.04	2.18 ± 0.12^***	1.97 ± 0.25^***
Food efficiency ratio (%)	1.04 ± 0.26	4.13 ± 0.55^***	2.81 ± 0.63^***,##
Cholesterol (mg/dL)	78.7 ± 9.7	170.2 ± 16.5^***	148.7 ± 15.4^***,#
Triglyceride (mg/dL)	73.8 ± 8.3	104.5 ± 5.3^***	70.6 ± 8.8^###
NEFA (mmol/L)	1.51 ± 0.25	1.39 ± 0.27	1.20 ± 0.42
Leptin (ng/mL)	638.8 ± 179.8	3670.8 ± 1272.7^***	1616.4 ± 393.7^***,###
Adiponectin (ng/mL)	26.5 ± 2.4	22.6 ± 2.4^**	24.3 ± 2.7
Glucose (mg/mL)	104.8 ± 19.9	189.2 ± 16.9^***	175.0 ± 33.1^***
Insulin (mg/mL)	14.07 ± 9.37	149.44 ± 28.35^***	98.87 ± 47.99^*
Liver weight (g)	1.00 ± 0.05	0.95 ± 0.06	0.99 ± 0.03
AST (U/L)	66.6 ± 18.9	285.5 ± 32.1^***	74.4 ± 18.6^###
ALT (U/L)	32.5 ± 5.0	61.8 ± 22.7^**	39.2 ± 14.6^#
Hepatic cholesterol (mg/dL)	44.2 ± 4.3	108.2 ± 26.2^***	81.3 ± 20.5^***,#
Hepatic triglyceride (mg/dL)	161.2 ± 30.6	244.1 ± 47.8^***	134.0 ± 26.8^###

C57Bl/6J mice were fed a normal diet (ND), a high-fat diet (HFD), or a HFD + L. plantarum K21 (10⁹ CFU per day) for eight weeks. Data represent the means ± SD of eight mice per group. < 0.05, < 0.01, and < 0.001 versus the ND group; < 0.05, < 0.01, and < 0.001 versus the HFD group.