Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells

Figure 5

Predicted interaction between ligands (SFN and TSA) with HDAC1. The HDAC1 protein is depicted in ribbon representation showing docked model of SFN in red and TSA in blue and the residues defining the pocket as light blue. The TSA structure was transformed from HDAC8 by superimposition on HDAC1. Inset focuses on the binding pocket shown in orange. The active site H-141 and Zn ion are labeled and highlighted in purple.