Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina
Table 1
Antinociceptive effect of ethanol extract of leaves of A. pavonina and morphine and reversal effect of naloxone in hot plate test.
Treatment (mg/Kg)
Response time (s) (% MPE)
Pretreatment
30 min
60 min
90 min
120 min
Control (0.1 mL/mouse)
6.05 ± 0.19
6.24 ± 0.39
6.82 ± 021
7.46 ± 0.16
7.86 ± 0.28
Morphine (5)
6.21 ± 0.19
12.84 ± 0.84 (48.09)
15.03 ± 1.21 (63.99)
15.59 ± 0.61 (68.01)
15.83 ± 1.31 (69.75)
EEAP (50)
5.72 ± 0.74
7.84 ± 0.63 (14.90)
9.11 ± 0.65 (23.77)
9.97 ± 0.63 (29.81)
10.40 ± 0.31 (32.78)
EEAP (100)
6.31 ± 0.34
8.22 ± 0.41 (13.96)
10.58 ± 0.32 (31.17)
11.45 ± 1.00 (37.53)
11.58 ± 1.13 (38.45)
EEAP (200)
5.83 ± 0.66
8.85 ± 0.60 (21.35)
11.94 ± 0.10 (43.11)
12.96 ± 0.81 (50.32)
14.31 ± 0.52 (59.84)
NLX (2) + control (0.1 mL/mouse)
5.85 ± 0.43
5.92 ± 0.30
6.08 ± 0.33
6.32 ± 0.34
7.06 ± 0.22
NLX (2) + morphine (5)
6.01 ± 0.55
6.79 ± 0.72a (5.57)
7.94 ± 0.56a (13.81)
8.39 ± 0.58a (17.01)
10.27 ± 1.48a (30.47)
NLX (2) + EEAP (50)
5.92 ± 0.32
6.84 ± 0.37 (6.57)
7.10 ± 0.33 (8.44)
8.34 ± 0.84 (17.24)
8.81 ± 0.57 (20.53)
NLX (2) + EEAP (100)
5.89 ± 0.42
7.35 ± 0.44 (10.35)
7.55 ± 0.32b (11.76)
8.46 ± 0.56 (18.23)
9.08 ± 0.56 (22.58)
NLX (2) + EEAP (200)
6.03 ± 0.42
7.54 ± 0.59 (10.82)
8.60 ± 0.32c (18.40)
9.45 ± 0.50c (24.52)
10.95 ± 0.69 (35.26)
Each value is presented as the mean ± SEM (). EEAP = ethanol extract of A. pavonina; NLX = naloxone; compared with the control group (Dunnett’s test); compared with the control group (Dunnett’s test); compared with the morphine group (Bonferroni’s test); compared with the EEAP 100 mg/kg group (Bonferroni’s test); compared with the EEAP 200 mg/kg group (Bonferroni’s test).
