Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina
Table 2
Antinociceptive effect of ethanol extract of leaves of A. pavonina and morphine and reversal effect of naloxone in tail immersion test.
Treatment (mg/Kg)
Response time (s) (% MPE)
Pretreatment
30 min
60 min
90 min
120 min
Control (0.1 mL/mouse)
1.88 ± 0.22
2.16 ± 0.39
2.38 ± 0.15
2.56 ± 0.18
2.74 ± 0.18
Morphine (5)
1.74 ± 0.05
3.12 ± 0.30 (7.58)
3.93 ± 0.21 (11.98)
4.37 ± 0.27 (14.43)
4.48 ± 0.04 (15.01)
EEAP (50)
1.75 ± 0.11
2.33 ± 0.14 (3.21)
2.72 ± 0.22 (5.35)
2.96 ± 0.27 (6.64)
3.16 ± 0.16 (7.77)
EEAP (100)
1.94 ± 0.32
2.80 ± 0.15 (4.76)
3.28 ± 0.11 (7.41)
3.63 ± 0.13 (9.33)
3.78 ± 0.41 (10.15)
EEAP (200)
1.99 ± 0.20
2.95 ± 0.19 (5.36)
3.58 ± 0.17 (8.87)
4.09 ± 0.19 (11.67)
4.02 ± 0.22 (11.27)
NLX (2) + control (0.1 mL/mouse)
1.79 ± 0.05
1.99 ± 0.22
1.97 ± 0.14
2.11 ± 0.23
2.23 ± 0.22
NLX (2) + morphine (5)
1.65 ± 0.10
2.07 ± 0.17 (2.29)
2.78 ± 0.25a (6.17)
2.91 ± 0.20a (6.87)
3.24 ± 0.21a (8.69)
NLX (2) + EEAP (50)
1.71 ± 0.16
2.14 ± 0.15 (2.36)
2.30 ± 0.16 (3.25)
2.46 ± 0.16 (4.10)
2.97 ± 0.27 (6.88)
NLX (2) + EEAP (100)
1.89 ± 0.35
2.31 ± 0.14 (2.31)
2.45 ± 0.13 (3.09)
2.54 ± 0.18b (3.57)
3.20 ± 0.19 (7.21)
NLX (2) + EEAP (200)
1.65 ± 0.25
2.50 ± 0.28 (4.64)
2.66 ± 0.17c (5.50)
3.08 ± 0.29 (7.80)
3.31 ± 0.18 (9.05)
Each value is presented as the mean ± SEM (). EEAP = ethanol extract of A. pavonina; NLX = naloxone; compared with the control group (Dunnett’s test); compared with the control group (Dunnett’s test); compared with the morphine group (Bonferroni’s test); compared with the EEAP 100 mg/kg group (Bonferroni’s test); compared with the EEAP 200 mg/kg group (Bonferroni’s test).
