Antiplatelet Aggregation and Antithrombosis Efficiency of Peptides in the Snake Venom of Deinagkistrodon acutus: Isolation, Identification, and Evaluation

Figure 3

Effects of Pt-A and Pt-B on paralysis that was induced by ADP in mice. The mice in each group were injected intravenously (IV) with the following: saline; clopidogrel (40 mg kg⁻¹), a positive control; Pt-A (10 mg kg⁻¹, 20 mg kg⁻¹, and 40 mg kg⁻¹) and Pt-B (20 mg kg⁻¹, 40 mg kg⁻¹, and 80 mg kg⁻¹). After 15 min, ADP (200 mg kg⁻¹) was IV injected to induce paralysis. The time that the mice come back to move was recorded as the paralysis time, which was presented as the mean ± SD. All the data were compared to the saline group and analyzed by unpaired Student’s -test. .