TCM Formula Xiaoyaosan Decoction Improves Depressive-Like Behaviors in Rats with Type 2 Diabetes

Figure 5

Histology of rat hippocampal structure in CA1, CA3, and DG subregions. Changes were found predominately in the CA1 and dentate gyms (DG) region of the hippocampus, rather than the CA3 subregion as seen in the pictures. Compared with group N and group T, obvious damage in hippocampal neurons appeared condensed and pyknotic in group T+D after high fat diet, STZ injection, and chronic restraint stress. The chromatins were in order, neurons increased, and less condensed and damaged neurons were found in group XYS and group F, compared with group T+D.

(a) CA1

(b) CA3

(c) DG