Scutellarin Reduces Endothelium Dysfunction through the PKG-I Pathway

Table 1

Effect of SCU and PKG inhibitor administrations on ACh and in BA rings.

Group	Dosage (i.v.)		EC50 (µM)	(% of U46619)
Sham	NS	12	0.39 ± 0.14	79.06 ± 6.57
Model	NS	11	1.11 ± 0.47	36.46 ± 4.90
SCU	45 mg/kg	8	NA	22.47 ± 7.59
SCU	90 mg/kg	11	0.30 ± 0.17	64.33 ± 4.40
PKG inhibitor	50 g/kg	8	NA	25.24 ± 7.19
SCU + PKG inhibitor	90 mg/kg + 50 g/kg	15	NA	15.1 ± 4.90

Data are means ± SEM; PKG inhibitor: Rp-8-Br-cGMPS; is the maximum vasodilative effect that ACh caused; EC₅₀ is the ACh concentration that makes 50% of the maximum vasodilative effect. : BA segments’ number; in each group blood vessel rings were obtained from 3-4 rats with different treatments. Blood vessel rings in each group were pretreated by tail intravenous injection with SCU or NS; NA: not available as relaxative response is too weak to be tested; NS: normal saline; one-way ANOVA on Rank Kruskal-Wallis test, versus model, ; , versus SCU (90 mg/kg), , .