Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats

Figure 1

CTX ameliorated body weight loss, 24 h proteinuria excretion, and plasma protein abnormality in ADR nephropathy rats. Adriamycin (ADR, 6 mg/kg) was administered through tail vein injection to induce nephropathy. CTX membrane strips at doses of 5, 15, and 45 μg/kg were administrated to Wistar rats once a day under the tongue 5 days before ADR and continued to the end of experiment. Body weight was measured once a week during the entire experimental period after ADR administration (a). Urine was collected for determination of 24 h proteinuria once a week before and after ADR injection (b). Rats were killed at 6th week and blood samples were collected for determination of serum levels of total protein (c), albumin (d), globulin (e), and albumin/globulin ratio (f). and compared with “Control” group; , , and compared with “ADR + Saline” group, –26.

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