Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 450581, 15 pages
http://dx.doi.org/10.1155/2015/450581
Research Article

Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China

Received 8 June 2015; Revised 9 September 2015; Accepted 29 September 2015

Academic Editor: Giuseppe Morgia

Copyright © 2015 Shu-Zhi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Jha, G. Garcia-Garcia, K. Iseki et al., “Chronic kidney disease: global dimension and perspectives,” The Lancet, vol. 382, no. 9888, pp. 260–272, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. R. B. Weiss, “The anthracyclines: will we ever find a better doxorubicin?” Seminars in Oncology, vol. 19, no. 6, pp. 670–686, 1992. View at Google Scholar · View at Scopus
  3. G. Bacci, S. Ferrari, F. Bertoni et al., “Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report,” Journal of Clinical Oncology, vol. 18, no. 24, pp. 4016–4027, 2000. View at Google Scholar · View at Scopus
  4. O. Tacar, P. Sriamornsak, and C. R. Dass, “Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems,” Journal of Pharmacy and Pharmacology, vol. 65, no. 2, pp. 157–170, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Okuda, Y. Oh, H. Tsuruda, K. Onoyama, S. Fujimi, and M. Fujishima, “Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease,” Kidney International, vol. 29, no. 2, pp. 502–510, 1986. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Wang, Y. P. Wang, Y.-C. Tay, and D. C. H. Harris, “Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events,” Kidney International, vol. 58, no. 4, pp. 1797–1804, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Y. Fan, M. Y. Yang, D. Qi et al., “Salvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats,” Scientific Reports, vol. 5, article 12273, 2015. View at Publisher · View at Google Scholar
  8. A. Hamada, S. Yoshioka, D. Takuma et al., “The effect of Eriobotrya japonica seed extract on oxidative stress in adriamycin-induced nephropathy in rats,” Biological and Pharmaceutical Bulletin, vol. 27, no. 12, pp. 1961–1964, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. G. K. Rangan, Y. Wang, Y.-C. Tay, and D. C. H. Harris, “Inhibition of nuclear factor-κB activation reduces cortical tubulointerstitial injury in proteinuric rats,” Kidney International, vol. 56, no. 1, pp. 118–134, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. C. Cheng, C. A. Chen, J. M. Chang, and H. C. Chen, “Albumin overload down-regulates integrin-beta1 through reactive oxygen species-endoplasmic reticulum stress pathway in podocytes,” The Journal of Biochemistry, 2015. View at Publisher · View at Google Scholar
  11. D. Kerjaschki, “Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis,” The Journal of Clinical Investigation, vol. 108, no. 11, pp. 1583–1587, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. T. S. Ha, “Roles of adaptor proteins in podocyte biology,” World Journal of Nephrology, vol. 2, no. 1, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  13. X. Li, P. Y. Chuang, V. D. D'Agati et al., “Nephrin preserves podocyte viability and glomerular structure and function in adult kidneys,” Journal of the American Society of Nephrology, vol. 26, no. 10, pp. 2361–2377, 2015. View at Publisher · View at Google Scholar
  14. S. Li, J. Wang, X. Zhang et al., “Proteomic characterization of two snake venoms: Naja naja atra and Agkistrodon halys,” Biochemical Journal, vol. 384, no. 1, pp. 119–127, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Cui, J. Q. Kou, J. Gu et al., “Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress,” BMC Complementary and Alternative Medicine, vol. 14, article 461, 2014. View at Publisher · View at Google Scholar
  16. J.-Q. Kou, R. Han, Y.-L. Xu et al., “Differential effects of Naja naja atra venom on immune activity,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 287631, 12 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. K.-Z. Zhu, Y.-L. Liu, J.-H. Gu, and Z.-H. Qin, “Antinociceptive and anti-inflammatory effects of orally administrated denatured naja naja atra venom on murine rheumatoid arthritis models,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 616241, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Zhu, K. Cui, J. Kou et al., “Naja naja atra venom protects against manifestations of systemic lupus erythematosus in MRL/lpr mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 969482, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. G.-N. Shi, Y.-L. Liu, H.-M. Lin et al., “Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin,” Acta Pharmacologica Sinica, vol. 32, no. 10, pp. 1233–1238, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. Y.-L. Liu, H.-M. Lin, R. Zou et al., “Suppression of complete freund's adjuvant-induced adjuvant arthritis by cobratoxin,” Acta Pharmacologica Sinica, vol. 30, no. 2, pp. 219–227, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. H. Park, H. S. Song, K. H. Kim et al., “Cobrotoxin inhibits NF-kappa B activation and target gene expression through reaction with NF-kappa B signal molecules,” Biochemistry, vol. 44, no. 23, pp. 8326–8336, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. Y.-L. Xu, J.-Q. Kou, S.-Z. Wang, C.-X. Chen, and Z.-H. Qin, “Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats,” International Immunopharmacology, vol. 28, no. 1, pp. 188–198, 2015. View at Publisher · View at Google Scholar
  23. S.-Z. Wang, H. He, R. Han et al., “The protective effects of cobra venom from Naja naja atra on acute and chronic nephropathy,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 478049, 17 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. G. L. Dai, J. K. He, Y. Xie, R. Han, Z. H. Qin, and L. J. Zhu, “Therapeutic potential of naja naja atra venom in a rat model of diabetic nephropathy,” Biomedical and Environmental Sciences, vol. 25, no. 6, pp. 630–638, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. Z.-H. Ding, L.-M. Xu, S.-Z. Wang et al., “Ameliorating adriamycin-induced chronic kidney disease in rats by orally administrated cardiotoxin from Naja naja atra venom,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 621756, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. V. W. Lee and D. C. Harris, “Adriamycin nephropathy: a model of focal segmental glomerulosclerosis,” Nephrology, vol. 16, no. 1, pp. 30–38, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Kamgang, A. F. Foyet, J.-L. Essame, and J. Y. Ngogang, “Effect of methanolic fraction of Kalanchoe crenata on metabolic parameters in adriamycin-induced renal impairment in rats,” Indian Journal of Pharmacology, vol. 44, no. 5, pp. 566–570, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Nagano, S. Miyata, S. Obana et al., “Sevelamer hydrochloride (Renagel), a non-calcaemic phosphate binder, arrests parathyroid gland hyperplasia in rats with progressive chronic renal insufficiency,” Nephrology Dialysis Transplantation, vol. 16, no. 9, pp. 1870–1878, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. J. Sheen and W. H. Sheu, “Risks of rapid decline renal function in patients with type 2 diabetes,” World Journal of Diabetes, vol. 5, no. 6, pp. 835–846, 2014. View at Publisher · View at Google Scholar
  30. L. Afsharkhas and A. Tavasoli, “Renal function in children with febrile convulsions,” Iranian Journal of Child Neurology, vol. 8, no. 4, pp. 57–61, 2014. View at Google Scholar
  31. A. S. Levey, J. P. Bosch, J. B. Lewis, T. Greene, N. Rogers, and D. Roth, “A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group,” Annals of Internal Medicine, vol. 130, no. 6, pp. 461–470, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. M. G. Shlipak, M. D. Mattes, and C. A. Peralta, “Update on cystatin C: incorporation into clinical practice,” American Journal of Kidney Diseases, vol. 62, no. 3, pp. 595–603, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Singh, G. Singh, and A. K. Dinda, “Understanding podocytopathy and its relevance to clinical nephrology,” Indian Journal of Nephrology, vol. 25, no. 1, pp. 1–7, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Merscher, C. E. Pedigo, and A. J. Mendez, “Metabolism, energetics, and lipid biology in the podocyte—cellular cholesterol-mediated glomerular injury,” Frontiers in Endocrinology, vol. 5, article 169, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Lawson, J. Elliott, C. Wheeler-Jones, H. Syme, and R. Jepson, “Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury,” Veterinary Journal, vol. 203, no. 1, pp. 18–26, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Jia, X. Ma, B. Gui et al., “Sorafenib ameliorates renal fibrosis through inhibition of TGF-beta-induced epithelial-mesenchymal transition,” PLoS ONE, vol. 10, no. 2, Article ID e0117757, 2015. View at Publisher · View at Google Scholar · View at Scopus
  37. M.-S. Zou, J. Yu, G.-M. Nie, W.-S. He, L.-M. Luo, and H.-T. Xu, “1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss,” International Journal of Medical Sciences, vol. 7, no. 5, pp. 290–299, 2010. View at Google Scholar · View at Scopus
  38. N. R. Shah and F. Dumler, “Hypoalbuminaemia—a marker of cardiovascular disease in patients with chronic kidney disease stages II-IV,” International Journal of Medical Sciences, vol. 5, no. 6, pp. 366–370, 2008. View at Google Scholar · View at Scopus
  39. E. Muso, “Beneficial effect of LDL-apheresis in refractory nephrotic syndrome,” Clinical and Experimental Nephrology, vol. 18, no. 2, pp. 286–290, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. S.-C. Chen and C.-H. Tseng, “Dyslipidemia, kidney disease, and cardiovascular disease in diabetic patients,” Review of Diabetic Studies, vol. 10, no. 2-3, pp. 88–100, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. S. S. Waikar, G. C. Curhan, and S. M. Brunelli, “Mortality associated with low serum sodium concentration in maintenance hemodialysis,” American Journal of Medicine, vol. 124, no. 1, pp. 77–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Makhlough, E. Ilali, R. Mohseni, and S. Shahmohammadi, “Effect of intradialytic aerobic exercise on serum electrolytes levels in hemodialysis patients,” Iranian Journal of Kidney Diseases, vol. 6, no. 2, pp. 119–123, 2012. View at Google Scholar · View at Scopus
  43. N. Putcha and M. Allon, “Management of hyperkalemia in dialysis patients,” Seminars in Dialysis, vol. 20, no. 5, pp. 431–439, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Mathew, K. S. Tustison, T. Sugatani, L. R. Chaudhary, L. Rifas, and K. A. Hruska, “The mechanism of phosphorus as a cardiovascular risk factor in CKD,” Journal of the American Society of Nephrology, vol. 19, no. 6, pp. 1092–1105, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. A. A. Waheed, F. Pedraza, O. Lenz, and T. Isakova, “Phosphate control in end-stage renal disease: barriers and opportunities,” Nephrology Dialysis Transplantation, vol. 28, no. 12, pp. 2961–2968, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. S. Chen, X.-F. Meng, and C. Zhang, “Role of NADPH oxidase-mediated reactive oxygen species in podocyte injury,” BioMed Research International, vol. 2013, Article ID 839761, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Palipoch, “A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants,” The African Journal of Traditional, Complementary and Alternative medicines, vol. 10, no. 4, pp. 88–93, 2013. View at Google Scholar
  48. K. Matsubara, T. Higaki, Y. Matsubara, and A. Nawa, “Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia,” International Journal of Molecular Sciences, vol. 16, no. 3, pp. 4600–4614, 2015. View at Publisher · View at Google Scholar
  49. A. Ayala, M. F. Muñoz, and S. Argüelles, “Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 360438, 31 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Jing and S. Lee, “NF-κB in cellular senescence and cancer treatment,” Molecules and Cells, vol. 37, no. 3, pp. 189–195, 2014. View at Publisher · View at Google Scholar · View at Scopus
  51. M. S. Hayden and S. Ghosh, “Shared principles in NF-κB signaling,” Cell, vol. 132, no. 3, pp. 344–362, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. W. Mu, X. Ouyang, A. Agarwal et al., “IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease,” Journal of the American Society of Nephrology, vol. 16, no. 12, pp. 3651–3660, 2005. View at Publisher · View at Google Scholar · View at Scopus