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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 456354, 10 pages
http://dx.doi.org/10.1155/2015/456354
Research Article

Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats

1Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China
2The First Affiliated Hospital of Jinan University, 613 Huangpu Road West, Guangzhou, Guangdong 510632, China

Received 7 January 2015; Accepted 6 April 2015

Academic Editor: Zhang Tan

Copyright © 2015 Su-Hong Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The research tries to establish Wistar rat’s model of atherosclerosis for evaluating the antiatherosclerotic effect of hederagenin and exploring its antiatherosclerosis-related mechanisms. The statistical data have shown that hederagenin exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antiplatelet aggregation, liver protection, and anti-inflammation, indicating that hederagenin may exert a protective effect on vascular walls by improving lipid metabolism disorders and lipid deposition. The results show that hederagenin can correct the imbalance of endothelial function by inhibiting the release of large amounts of iNOS and increasing eNOS contents and inhibits the IKKβ/NF-κB signaling pathway to reduce the release of IL-6, IFN-γ, TNF-α, and other inflammatory factors. The experimental results indicated that hederagenin can inhibit or ameliorate the pathological changes associated with AS, displaying an excellent preventive function against AS.