Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series

Table 2

Characteristics of included case series.

Reference	Number of cases	Gender (F/M)	Age (a)	Duration of intake, day	Type of liver injury (number)	Outcome
Dong et al. [22]	18	5/13	18–63	1–120	H (18)	18 recoveries
Lian et al. [17]	52	22/30	22–69	5–120	H (30); C (9); M (13)	52 recoveries
Zhang et al. [24]	13	11/2	35–66	4–15	H (6); C (4); M (3)	12 recoveries; 1 LT
Zhang et al. [18]	36	13/23	24–73	NA	H (21); C (2); M (13)	33 recoveries; 1 cirrhosis; 2 deaths
Ding [26]	65	45/20	34–71	7–90	NA	64 recoveries; 1 death
Guo [28]	15	8/7	18–57	7–56	H (8); C (3); M (4)	15 recoveries
Xie et al. [27]	10	3/7	46.1 ± 10.2	30–105	H (5); C (4); M (1);	9 recoveries; 1 death
Song [29]	26	12/14	38–71	9–93	NA	26 recoveries
Wang [30]	20	7/13	34–67	NA	NA	20 recoveries
Jung et al. [25]	25	7/18	24–65	1–180	H (18); M (7)	23 recoveries; 1 LT; 1 death
Chen et al. [19]	12	5/7	20–70	15–90	H (4); C (4); M (4)	12 recoveries
Liu and Li [98]	7	5/2	31–64	60–180	NA	7 recoveries
Liu [20]	9	3/6	34–68	NA	NA	9 recoveries
Xu et al. [23]	40	24/16	45.2	9–168	H (22); C (8); M (10)	38 recoveries; 2 deaths
Yang et al. [99]	13	8/5	32–68	7–30	NA	13 recoveries
Zhou and Qiu [21]	11	5/6	34–58	NA	NA	11 recoveries
Zhang et al. [31]	6	3/3	24–50	4–24 w	NA	6 recoveries

NA: not available; H: hepatocellular; C: cholestatic; M: mixed; LT: liver transplantation.