Total Flavonoids from Clinopodium chinense (Benth.) O. Ktze Protect against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo

Figure 11

Effect of TFCC on the antitumor ability of doxorubicin. A series of cancer cell lines, including KB, HepG2, and MCF-7 cells, were treated with DOX (1 μM) with or without TFCC (25 μg/mL for 4 h prior to DOX exposure) for 24 h. Cell viability was determined using MTT assay (expressed as the percentage of control in each cell line). Cont, vehicle treatment; TFCC, TFCC treatment; DOX, DOX treatment; TFCC + DOX, TFCC and DOX cotreatment. Results are represented as the mean ± SE. relative to the control group, and relative to the DOX group.