Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca

Figure 2

Identification of the anti-inflammatory component “K100” in Cota palaestina: (a) effect of II.1, II.2, II.3, and II.4 fractions (10 g/mL). (b) Effect of subfractions (II.2.2, II.2.3, II.2.5, and II.2.7) at 10 g/mL on IL-6 production and (c) dose-dependent inhibition of IL-6 production by fraction II.2.5 at 1, 3, 6, 9, and 12 g/mL. (d) Purification and structure of the anti-inflammatory component “K100” in Cota palaestina. Diagram summarizing the fractionation of Cota palaestina extract. (−) indicates no suppression of IL-6 production by ET-treated SCp2 cells and (+) indicates suppression of IL-6 production. Chemical structure of K100, the germacranolide 1-,10--Epoxy-6-hydroxy-1,10H-inunolide. Statistical significance is represented by () asterisk indicating significant difference at .

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