Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca

Figure 4

In silico molecular docking shows that K100 exhibits PTL-analogous predicted binding to known PTL targets: (a) chemical structure of the four K100 stereoisomers and the other two SLs included in the docking simulations, PTL and DMAPT. (b) Predicted binding affinities of K100 (1), K100 (2), K100 (3), K100 (4), PTL, and DMAPT to IKKb, p65, p38, JNK1, JNK2, Stat3b, Stat6, TNFR1, GSH, Actin, GAPDH, and Albumin. Numbers shown represent averages of 5 independent simulations standard deviation (SD). Statistical significance is represented by asterisk () at .

(a)

(b)