Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca

Figure 5

Effect of K100 versus PTL on the proliferation and cell cycle progression of MDA-MB-231 cells under 2D culture conditions: (a) effect of different concentrations of K100 versus PTL on MDA-MB-231 cell proliferation after treatment for 24, 48, and 72 hrs. Cellular viability was measured by trypan blue exclusion dye assay. (b) Table representing percentage of cells in G0/G1, S, and G2/M phases of cell cycle in control cells and cells treated with K100 versus PTL. Histogram plot showing cell counts in S-phase with respect to untreated cells. Statistical significance is represented by () asterisk indicating significant difference at , and () asterisk indicating significant difference at .

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