Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet

Table 1

Effects of the administration of the methanolic extract of Vitex megapotamica (MEVM) and simvastatin (SIMV) on urinary density from LDLr-null mice.

Group	Density (g/L)
	Outset	Week 1	Week 2	Week 3	Week 4	Week 5
N. control	1004 ± 0.3	1005 ± 0.9	1004 ± 0.7	1006 ± 0.7	1004 ± 0.9	1005 ± 0.6
P. control	1005 ± 0.6	1006 ± 1.0	1007 ± 0.9	1007 ± 0.8	1008 ± 1.1	1011 ± 1.0^b
MEVM (30)	1006 ± 0.8	1007 ± 0.9	1005 ± 0.6	1006 ± 0.9	1007 ± 0.8	1007 ± 0.9
MEVM (100)	1005 ± 0.5	1004 ± 0.6	1005 ± 0.4	1006 ± 0.7	1005 ± 0.6	1006 ± 0.5^a
MEVM (300)	1006 ± 0.8	1006 ± 0.7	1004 ± 0.7	1005 ± 0.9	1006 ± 0.8	1006 ± 0.7^a
SIMV (40)	1005 ± 0.5	1004 ± 0.6	1005 ± 0.8	1005 ± 0.6	1006 ± 0.6	1005 ± 1.3^a

Values are expressed as mean ± SEM ( in each group) in comparison to the positive control (^a < 0.05) or negative control (^b < 0.05) using one-way ANOVA followed by Bonferroni test.