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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 483942, 6 pages
Research Article

Study on the Antinociceptive Effects of Herba Epimedium in Mice

1Department of Animal Biotechnology, College of Veterinary Medicine, Northwest A & F University, Yangling 712100, China
2Henan Soar Veterinary Pharmaceutical Co., Ltd., Zhengzhou, Henan 45008, China

Received 8 December 2014; Revised 20 April 2015; Accepted 21 April 2015

Academic Editor: Vincenzo De Feo

Copyright © 2015 Jiang-hong Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study was conducted to investigate the antinociceptive action of relationship between Herba Epimedium (HE) and receptor, between Herba Epimedium (HE) and receptor. We used the hot-plate method and the writhing assay in mice by the intracerebroventricular (i.c.v.) injection and observed the analgesic effect of HE. Furthermore, through the i.c.v. injection, receptor partial agonist Buspirone, antagonist Propranolol, the adrenaline -receptor selective blocking agent Metoprolol, and receptor agonist hydrochloride DOI and antagonist Ketanserin were used, and, 5 min later, HE was used to investigate the impacts of drugs on the analgesic effect in the same way. Results showed that HE had fast and significant antinociception in nervous system, and the effects can persist for a long time. Buspirone and Hydrochloride DOI can remarkably increase the antinociception of HE in nervous system. Ketanserin leads to a significant decrease in its antinociception in nervous system; Metoprolol also has antinociceptive action in nervous system, but it can inhibit the antinociceptive effect of Herba Epimediumin peripheral region. These results suggest that HE has significant antinociception effect and its mechanism is related with receptor, receptor, and adrenaline -receptor.