Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis

Figure 3

The therapeutic effects of OD for survival and glucose metabolism after HCC. Experimental scheme to test the effect of OD on the survival or ¹⁸F-FDG uptake in HCC model (a). The survival of HCC was analyzed by a log-rank test based on the Kaplan-Meier method (b). We recorded starting from day 0 after the last DEN injection. We record death rate between 20 days and 36 days (c). ¹⁸F-FDG PET was scanned at day 0 and 28 days after OD treatment. At 28 days after OD treatment, liver of rats in control group was significantly enhanced uptake of ¹⁸F-FDG into generated HCC and showed multinodular HCC. However, uptake of ¹⁸F-FDG on rat’s liver in OD (100 and 200 mg) treated group was decreased compared to the control group (d). Quantitative analysis of ¹⁸F-FDG uptake analyzed at day 0 and 28 days after OD treatment (e). The relative SUV of OD treated group was decreased compared to the control group. Columns, mean; bar, SD. .

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