The Intervention Effects of Acupuncture on Fatigue Induced by Exhaustive Physical Exercises: A Metabolomics Investigation
Table 1
The change trends of discriminitive metabolites between groups.
Metabolites
1H (ppm)
% average changes in TA relatively to TR (, VIP, ) ()
% average changes in T35 relatively to T0 (, VIP, ) excluding Lac ()
% average changes in T35 relatively to T0 (, VIP, ) ()
% average changes in TA relatively to T0 (, VIP, ) ()
% average changes in TR relatively to T0 (, VIP, ) ()
2HB
0.90
−19.3 (0.46, 0.24, 0.10)
+242.2 (0.93, 2.81, 0.00)
/
+20.4 (0.67, 0.20, 0.00)
+49.2 (0.81, 0.42, 0.02)
Leu
0.95
/
+31.3 (0.91, 1.36, 0.00)
/
/
/
IB
1.08
/
+27.4 (0.70, 1.20, 0.02)
/
/
/
3AIB
1.20
−43.1 (0.20, 2.08, 0.16)
/
/
−17.6 (0.18, 1.12, 0.73)
+44.9 (0.22, 1.44, 0.46)
3HIV
1.24
+5.6 (0.66, 1.80, 0.28)
−56.5 (0.56, 1.47, 0.00)
/
+2.9 (0.28, 1.47, 0.80)
−2.6 (0.23, 0.97, 0.78)
Lac
1.34
−46.4 (0.56, 16.2, 0.03)
/
+7770.5 (0.97, 27.9, 0.00)
+456.5 (0.90, 19.2, 0.00)
+932.2 (0.72, 25.3, 0.00)
Ala
1.48
/
+56.0 (0.50, 1.84, 0.02)
/
−26.4 (0.60, 1.30, 0.19)
−14.7 (0.24, 1.16, 0.23)
Pyr
2.35
+73.7 (0.43, 2.36, 0.07)
−20.0 (0.26, 1.07, 0.17)
/
+32.7 (0.27, 1.35, 0.20)
−23.6 (0.21, 0.53, 0.15)
Suc
2.38
/
+1434.8 (0.91, 30.0, 0.00)
/
+124.2 (0.90, 2.03, 0.00)
+121.4 (0.88, 1.38, 0.01)
Gln
2.45
/
−25.7 (0.72, 1.69, 0.00)
/
−23.4 (0.61, 1.21, 0.01)
−14.5 (0.44, 0.79, 0.12)
Cit
2.55
+52.5 (0.48, 1.88, 0.07)
−64.0 (0.68, 8.26, 0.00)
/
−33.6 (0.54, 4.97, 0.04)
−56.5 (0.56, 6.07, 0.00)
DMA
2.72
−14.7 (0.45, 1.06, 0.02)
−6.6 (0.36, 0.99, 0.18)
/
−2.2 (0.29, 0.48, 0.35)
+14.7 (0.18, 0.70, 0.10)
DMG
2.93
+11.2 (0.09, 0.32, 0.26)
−29.8 (0.48, 1.83, 0.000)
−10.4 (0.42, 0.67, 0.21)
−19.5 (0.34, 0.84, 0.04)
Crn
3.04
−6.2 (0.67, 25.9, 0.04)
/
+3.9 (0.07, 8.26, 0.20)
−3.5 (0.06, 4.89, 0.23)
+2.9 (0.03, 10.5, 0.292)
Cho
3.21
+83.9 (0.17, 2.68, 0.12)
−3.6 (0.06, 0.26, 0.34)
/
+167.8 (0.44, 3.59, 0.06)
+45.6 (0.46, 1.30, 0.07)
TMAO
3.27
−18.4 (0.19, 1.25, 0.10)
−31.5 (0.51, 3.63, 0.03)
/
−24.8 (0.25, 7.56, 0.09)
−7.8 (0.20, 4.02, 0.33)
Tau
3.43
−37.3 (0.24, 1.52, 0.08)
−28.5 (0.47, 1.23, 0.02)
/
+3.4 (0.23, 0.61, 0.44)
+64.9 (0.33, 2.22, 0.07)
Gly
3.57
+14.9 (0.33, 1.12, 0.11)
−60.0 (0.82, 17.2, 0.000)
−60.0 (0.82, 17.2, 0.000)
−53.0 (0.74, 11.98, 0.00)
−59.1 (0.43, 11.87, 0.00)
Hip
7.83
+176.2 (0.75, 3.17, 0.01)
−21.7 (0.17, 0.99, 0.26)
/
−18.8 (0.08, 0.31, 0.28)
−70.6 (0.33, 3.66, 0.01)
Hyx
8.19
−46.2 (0.55, 1.02, 0.01)
+2000.0 (0.87, 4.49, 0.00)
/
+648.9 (0.79, 1.23, 0.02)
+1292.6 (0.78, 2.54, 0.00)
For
8.46
/
−69.6 (0.57, 1.64, 0.00)
/
−48.0 (0.51, 0.95, 0.01)
−57.7 (0.45, 0.92, 0.00)
“+” means an increase. “−” means a decrease. “/” means no significant change ( < the cut-off value, VIP < 1 and/or ). The absolute values of correlation number extracted from the correlation plots of OPLS-DA models. The cut-off values are 0.532 in the coefficient plot of TA versus TR, 0.404 in the coefficient plot of T35 versus T0, and 0.433 in the coefficient plot of TA versus T0 and TR versus T0. The values were obtained from one-way ANOVA.
