Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57/BL6 Mice

Table 1

Changes of oxidative stress and antioxidant system components.

Groups	Naive; (fold)	Control; (fold)	TCW (fold)			Gallic acid; 100 mg/kg (fold)
			50 mg/kg	100 mg/kg	200 mg/kg
MDA contents	11.7 ± 2.4	22.0 ± 8.1^#	14.3 ± 3.3	12.3 ± 3.4^*	10.2 ± 0.9^*	13.8 ± 2.9
(μM/mg protein)	(1.0 ± 0.2)	(1.9 ± 0.4)	(1.2 ± 0.2)	(1.0 ± 0.3)	(0.9 ± 0.1)	(1.2 ± 0.2)
Total ROS	21.2 ± 1.9	44.3 ± 9.1^##	32.0 ± 9.3	35.1 ± 6.4	23.4 ± 5.5^**	21.5 ± 4.2^**
(U/mg protein)	(1.0 ± 0.1)	(2.1 ± 0.2)	(1.4 ± 0.3)	(1.7 ± 0.2)	(1.1 ± 0.2)	(1.0 ± 0.2)
NO	10.1 ± 0.6	16.1 ± 6.3^#	13.5 ± 2.3	11.3 ± 0.8	10.6 ± 0.8^*	12.9 ± 2.3
(μM/mg protein)	(1.0 ± 0.1)	(1.6 ± 0.4)	(1.3 ± 0.2)	(1.1 ± 0.1)	(1.0 ± 0.1)	(1.3 ± 0.2)
TAC	636.3 ± 158.4	443.7 ± 87.7^#	557.3 ± 127.2	721.4 ± 126.1^*	776.4 ± 200.8^**	742.2 ± 139.8^**
(μM/mg protein)	(1.0 ± 0.2)	(0.7 ± 0.2)	(0.9 ± 0.2)	(1.1 ± 0.2)	(1.2 ± 0.3)	(1.2 ± 0.2)
Total GSH	85.8 ± 6.2	59.9 ± 18.3^##	86.2 ± 7.2^**	83.9 ± 7.9^**	85.9 ± 4.3^**	81.7 ± 6.8^*
(uM/mg protein)	(1.0 ± 0.1)	(0.7 ± 0.3)	(1.0 ± 0.1)	(1.0 ± 0.1)	(1.0 ± 0.1)	(1.0 ± 0.1)
GSH-Px	53.9 ± 11.4	36.0 ± 5.3^##	45.5 ± 10.2	40.6 ± 8.3	47.2 ± 7.7^*	42.9 ± 21.1
(U/mg protein)	(1.0 ± 0.2)	(0.7 ± 0.3)	(0.8 ± 0.3)	(0.8 ± 0.2)	(0.9 ± 0.2)	(0.8 ± 0.5)
GSH-Rd	37.4 ± 3.6	32.4 ± 6.2	46.8 ± 15.6	38.6 ± 17.1	51.1 ± 17.1^*	45.0 ± 7.7^*
(U/mg protein)	(1.0 ± 0.1)	(0.9 ± 0.2)	(1.3 ± 0.3)	(1.0 ± 0.4)	(1.4 ± 0.3)	(1.2 ± 0.2)
SOD activity	22.3 ± 3.5	18.3 ± 1.4^#	29.2 ± 8.3^*	27.4 ± 3.1^***	29.8 ± 2.5^***	25.9 ± 3.4^**
(U/mg protein)	(1.0 ± 0.2)	(0.8 ± 0.1)	(1.3 ± 0.3)	(1.2 ± 0.1)	(1.3 ± 0.1)	(1.2 ± 0.1)
CAT activity	927.1 ± 145.7	681.4 ± 141.8^#	972.9 ± 324.4	1111.2 ± 183.9^**	985.1 ± 201.0^*	895.7 ± 318.8
(U/mg protein)	(1.0 ± 0.2)	(0.7 ± 0.2)	(0.7 ± 0.3)	(1.2 ± 0.2)	(1.1 ± 0.2)	(1.0 ± 0.4)

Data were expressed as the mean ± SD ( = 6). < 0.05 and < 0.01 compared with the naive group; < 0.05, < 0.01, and < 0.001 compared with the control group. The figures shown in parentheses were normalized by each value of the naive group.