Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 1

Research Article

Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57/BL6 Mice

Table 1

Changes of oxidative stress and antioxidant system components.

Groups Naive
(fold)
Control
(fold)
TCW (fold) Gallic acid
100 mg/kg (fold)
50 mg/kg100 mg/kg200 mg/kg

MDA contents11.7 ± 2.422.0 ± 8.1#14.3 ± 3.312.3 ± 3.4*10.2 ± 0.9*13.8 ± 2.9
(μM/mg protein)(1.0 ± 0.2)(1.9 ± 0.4)(1.2 ± 0.2)(1.0 ± 0.3)(0.9 ± 0.1)(1.2 ± 0.2)

Total ROS21.2 ± 1.944.3 ± 9.1##32.0 ± 9.335.1 ± 6.423.4 ± 5.5**21.5 ± 4.2**
(U/mg protein)(1.0 ± 0.1)(2.1 ± 0.2)(1.4 ± 0.3)(1.7 ± 0.2)(1.1 ± 0.2)(1.0 ± 0.2)

NO 10.1 ± 0.616.1 ± 6.3#13.5 ± 2.311.3 ± 0.810.6 ± 0.8*12.9 ± 2.3
(μM/mg protein)(1.0 ± 0.1)(1.6 ± 0.4)(1.3 ± 0.2)(1.1 ± 0.1)(1.0 ± 0.1)(1.3 ± 0.2)

TAC636.3 ± 158.4443.7 ± 87.7#557.3 ± 127.2721.4 ± 126.1*776.4 ± 200.8**742.2 ± 139.8**
(μM/mg protein)(1.0 ± 0.2)(0.7 ± 0.2)(0.9 ± 0.2)(1.1 ± 0.2)(1.2 ± 0.3)(1.2 ± 0.2)

Total GSH85.8 ± 6.259.9 ± 18.3##86.2 ± 7.2**83.9 ± 7.9**85.9 ± 4.3**81.7 ± 6.8*
(uM/mg protein)(1.0 ± 0.1)(0.7 ± 0.3)(1.0 ± 0.1)(1.0 ± 0.1)(1.0 ± 0.1)(1.0 ± 0.1)

GSH-Px53.9 ± 11.436.0 ± 5.3##45.5 ± 10.240.6 ± 8.347.2 ± 7.7*42.9 ± 21.1
(U/mg protein)(1.0 ± 0.2)(0.7 ± 0.3)(0.8 ± 0.3)(0.8 ± 0.2)(0.9 ± 0.2)(0.8 ± 0.5)

GSH-Rd37.4 ± 3.632.4 ± 6.246.8 ± 15.638.6 ± 17.151.1 ± 17.1*45.0 ± 7.7*
(U/mg protein)(1.0 ± 0.1)(0.9 ± 0.2)(1.3 ± 0.3)(1.0 ± 0.4)(1.4 ± 0.3)(1.2 ± 0.2)

SOD activity22.3 ± 3.518.3 ± 1.4#29.2 ± 8.3*27.4 ± 3.1***29.8 ± 2.5***25.9 ± 3.4**
(U/mg protein)(1.0 ± 0.2)(0.8 ± 0.1)(1.3 ± 0.3)(1.2 ± 0.1)(1.3 ± 0.1)(1.2 ± 0.1)

CAT activity927.1 ± 145.7681.4 ± 141.8#972.9 ± 324.41111.2 ± 183.9**985.1 ± 201.0*895.7 ± 318.8
(U/mg protein)(1.0 ± 0.2)(0.7 ± 0.2)(0.7 ± 0.3)(1.2 ± 0.2)(1.1 ± 0.2)(1.0 ± 0.4)

Data were expressed as the mean ± SD ( = 6). < 0.05 and < 0.01 compared with the naive group; < 0.05, < 0.01, and < 0.001 compared with the control group. The figures shown in parentheses were normalized by each value of the naive group.