The Mechanism Underlying the Antibacterial Activity of Shikonin against Methicillin-Resistant Staphylococcus aureus

Figure 6

Transmission electron microscopy images of SKN-treated MRSA (ATCC 33591) cells. (a) Untreated control MRSA cells; white arrows indicate intact cell membrane. (b) MRSA cells treated with SKN (7.8 μg/mL, 0.5 MIC) for 10 h; white arrows indicate significant membrane damage. (c) MRSA cells treated with SKN (15.6 μg/mL, MIC); black arrows indicate disrupted bacterial membrane and dispersed intracellular contents.

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