Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle

Figure 4

CEPN inhibits ACh-induced precontraction. (a) ACh induced a contraction in a tracheal ring that was inhibited completely by CEPN. This experiment was repeated in 6 rings. (b) Nifedipine partially reduced the ACh-induced contraction in a dose-dependent manner. The resistant contraction was inhibited by CEPN. The summary results from 6 experiments are shown in (c). (d) In the presence of nifedipine, ACh induced a typical contraction, which was dose-dependently inhibited by CEPN. The summary results from 6 experiments exhibited in (e). These results show that CEPN inhibits VDCCs and another pathway to induce relaxation.

(a)

(b)

(c)

(d)

(e)