Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle

Figure 5

Pyr3 inhibits ACh-induced contraction. (a) Pyr3, a blocker of TRPC3 and Orai1 channels, partially inhibited ACh-induced contraction in a dose-dependent manner. The remained contraction was completely blocked by 1 mg/mL CEPN. The dose-response from 4 experiments is shown in (b). (c) Comparison of the relaxant effects of CEPN, nifedipine, and Pyr3 on ACh-induced contraction. , .

(a)

(b)

(c)