Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats
Table 1
Treatment
Body weight (g)
Liver weight (g)
Liver index (%)
N
309 ± 11
11.63 ± 0.42
3.4 ± 0.04
SHR
267 ± 9#
11.10 ± 0.15
3.8 ± 0.04
N + APAP
321 ± 6
11.39 ± 0.33
3.7 ± 0.1*
SHR + APAP
248 ± 10##
10.12 ± 0.36
4.4 ± 0.1**
N + SLM + APAP
317 ± 8
11.02 ± 0.37
3.5 ± 0.07*
SHR + SLM + APAP
233 ± 4###
8.89 ± 0.34
3.4 ± 0.1**
Body weight (g), liver weight (g), and liver index (%) in all groups of rats 12 hours after APAP administration (3 g/kg) and pretreated with SLM (200 mg/kg). Media ± SEM, por grupo. N + APAP versus N, N + SLM + APAP versus N + APAP, SHR + APAP versus SHR, SHR + SLM + APAP versus SHR + APAP, N versus SHR, N + APAP versus SHR + APAP, and N + SLM + APAP versus SHR + SLM + APAP.
