Antiproliferative Effect of Rottlerin on Sk-Mel-28 Melanoma Cells

Figure 1

Rottlerin inhibits proliferation of Sk-Mel-28 melanoma cells. (a) Rottlerin treatment for 24 h reduced cell density, evaluated by the SRB assay, in a dose-dependent manner. (b) Time-dependent decrease of cell density after 24–72 h exposure to 20 μM Rottlerin. Results are the means ± SD of at least three independent experiments in triplicate and expressed as % of control. (c) Cell viability, evaluated by Trypan blue staining, after 24–72 h exposure to 20 μM Rottlerin. The percentage viability (live cell count/total cell count) was calculated and expressed as % of control. Results are the means ± SD of three independent experiments. Controls were exposed to DMSO alone; .

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