Preclinical Evaluation on the Tumor Suppression Efficiency and Combination Drug Effects of Fermented Wheat Germ Extract in Human Ovarian Carcinoma Cells

Table 2

Combination drug effects of FWGE with cisplatin or docetaxel in SKOV-3 and ES-2 cells. The combination drug index (CDI) was based on cell viability data obtained after 48 h of treatment with FWGE combined with cisplatin or docetaxel and was calculated using the CalcuSyn software. CDI < 1 indicates a synergistic effect; CDI = 1 indicates an additive effect; and CDI > 1 indicates an antagonistic effect.

SKOV-3		ES-2
	CDI		CDI
Cisplatin (M)		Cisplatin (M)
1	23.73	1	5.227
2.5	6.601	2.5	3.658
5	0.764	5	0.305
10	0.369	10	1.032
Docetaxel (nM)		Docetaxel (nM)
1	4.114	1	6.859
2.5	1.792	5	5.568
5	0.993	10	1.928
10	0.996	100	0.639