Type I Saikosaponins A and D Inhibit Osteoclastogenesis in Bone Marrow-Derived Macrophages and Osteolytic Activity of Metastatic Breast Cancer Cells
Cytotoxicity of saikosaponins on BMMs. (a) BMMs (5 × 104 cells/well) were incubated in α-MEM with 10% FBS, M-CSF (30 ng/mL), and each saikosaponin (1 and 10 μM) for 5 days. (b) BMMs were treated with saikosaponin A (SSA) or D (SSD) at the indicated concentrations for 5 days. Cell viability was determined by MTT assay. The data are expressed as the mean ± SE. * and ** versus BMMs without saikosaponins.
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