Evidence-Based Complementary and Alternative Medicine

Research Article

Chinese Herbal Medicine Combined with Conventional Therapy for Blood Pressure Variability in Hypertension Patients: A Systematic Review of Randomized Controlled Trials

Table 3

Effect estimate of Chinese herbal medicines for blood pressure variability in randomized clinical trials.

(a)

Intervention versus control

Effect estimate of outcomes (RR or MD (95% CI))

24 hsSD

24 hdSD

dsSD

ddSD

nsSD

ndSD

2 hsCV

24 hdCV

dsCV

ddCV

nsCV

ndCV

) Chinese medicine combined with conventional therapy versus the same conventional therapy

Xiandan tongmai decoction [22]

−2.40 −3.50, −1.30]

−1.60 −3.12, −0.08]

−1.40 −2.63, −0.17]

−1.90 −3.28, −0.52]

−1.40 −2.63, −0.17]

0.50 −1.10, 2.10]

Xuezhikang capsule [24]

−1.79 −2.79, −0.79]

−0.72 −1.97, 0.53]

Gouteng siwu decoction [28]

0.28 −1.31, 1.88]

−0.21 −1.31, 0.89]

Xiang tian ma decoction [23]

−5.20 −6.37, −4.03]

−0.67 −1.59, 0.25]

−4.56 −5.85, −3.27]

−1.14 −2.09, −0.19]

−6.18 −7.74, −4.62]

−1.19 −2.14, −0.24]

Qianyang yuyin granule [18]

−1.04 −2.74, 0.66]

−0.40 −1.64, 0.84]

−1.47 −3.39, 0.45]

−0.54 −1.96, 0.88]

−0.89 −3.85, 2.07]

−0.84 −2.69, 1.01]

Tianma shuxin granule [17]

−1.24 −2.65, 0.17]

−0.04 −1.11, 1.03]

−1.06 −2.30, 0.18]

−0.43 −1.64, 0.78]

−0.37 −2.27, 1.52]

−1.29 −3.18, 0.60]

−0.00 −0.01, 0.01]

0.03 0.02, 0.04]

−0.01 −0.02, −0.00]

−0.01 −0.02, 0.01]

−0.01 −0.03, 0.01]

Sangji wendan decoction [20]

−2.44 −4.38, −0.50]

−2.13 −4.34, 0.08]

−0.02 −2.21, 2.17]

−1.74 −4.14, 0.66]

−1.00 −3.33, 1.33]

−1.78 −4.34, 0.78]

Tiao ping kang tablet [27]

−0.40 −3.30, 2.50]

−0.62 −3.72, 2.48]

−3.87 −6.16, −1.58]

−4.95 −7.10, −2.80]

−5.29 −7.40, −3.18]

−1.82 −4.09, 0.45]

Yin gan jing decoction [26]

−0.90 −1.45, −0.35]

−0.24 −0.46, −0.02]

Yangxue qingnao granule [25]

−0.50 −0.81, −0.19]

−0.15 −0.50, 0.20]

−0.39 −0.60, −0.18]

−0.21 −0.36, −0.06]

Qin dan capsule [19]

−2.15 −3.39, −0.91]

−2.20 −3.26, −1.14]

−1.15 −2.21, −0.09]

−1.40 −2.51, −0.29]

Songling Xuemaikang capsule [21]

−0.70 −1.48, 0.08]

−0.60 −1.08, −0.12]

−1.60 −2.19, −1.01]

−0.10 −0.59, 0.39]

() Chinese medicine combined with conventional therapy versus placebo combined with the same conventional therapy

Qing xuan granule [29]

−1.47 −2.52, −0.42]

−1.26 −1.93, −0.59]

−1.60 −2.65, −0.55]

−1.02 −1.70, −0.34]

−2.02 −3.45, −0.59]

−1.54 −2.62, −0.46]

0.00 −0.01, 0.01]

−0.01 −0.07, 0.05]

0.00 −0.01, 0.02]

0.00 −0.01, 0.01]

−0.01 −0.02, 0.01]

−0.01 −0.03, 0.01]

(b)

Intervention versus control

Effect estimate of outcomes (RR or MD (95% CI))

24 hsBP

24 hdBP

dsBP

ddBP

nsBP

ndBP

Adverse effect

Quality of life

NSBPDR

NDBPDR

RARBPR

() Chinese medicine combined with conventional therapy versus the same conventional therapy

Xiandan tongmai decoction [22]

−0.20 −3.23, 2.83]

0.10 −2.66, 2.86]

−1.70 −4.93, 1.53]

−0.40 −3.40, 2.60]

1.10 −1.99, 4.19]

0.10 −2.66, 2.86]

0.59 0.22, 1.57]

Xuezhikang capsule [24]

−5.00 −8.80, −1.20]

−1.00 −3.07, 1.07]

0.80 0.29, 2.21]

Gouteng siwu decoction [28]

−14.65 −20.29, −9.01]

−4.05 −8.09, −0.01]

0.32 0.10, 1.04]

3.09 0.12, 78.41]

Xiang tian ma decoction [23]

−2.90 −6.27, 0.47]

−4.05 −7.23, −0.87]

3.50 0.42, 6.58]

−3.72 −5.23, −2.21]

−6.80 −12.85, −0.75]

−0.75 −3.29, 1.79]

0.25 0.05, 1.26]

Qianyang yuyin granule [18]

−9.60 −13.49, −5.71]

−6.45 −10.58, −2.32]

−9.85 −14.14, −5.56]

−0.84 −2.69, 1.01]

−7.80 −13.04, −2.56]

−6.40 −10.72, −2.08]

Tianma shuxin granule [17]

−0.20 −3.67, 3.27]

1.73 −2.83, 6.29]

2.00 −1.73, 5.73]

0.73 −3.08, 4.54]

−5.84 −15.76, 4.08]

1.46 −2.37, 5.29]

1.00 0.19, 5.40]

−0.01 [−0.02, 0.01]

−0.01 −0.03, 0.01]

Sangji wendan decoction [20]

0.52 −6.65, 7.69]

0.16 −4.47, 4.79]

−0.35 −8.01, 7.31]

−0.42 −5.50, 4.66]

1.46 −7.06, 9.98]

0.63 −4.75, 6.01]

0.32 0.01, 8.26]

Tiao ping kang tablet [27]

−0.10 −4.47, 4.27]

−1.00 −4.95, 2.95]

−3.40 −7.38, 0.58]

−2.90 −5.73, −0.07]

−8.70 −13.18, −4.22]

−4.00 −6.81, −1.19]

0.93 0.17, 5.02]

0.09 0.00, 1.74]

0.17 0.04, 0.66]

Yin gan jing decoction [26]

−2.92 −5.51, −0.33]

−2.57 −4.68, −0.46]

−3.15 −5.66, −0.64]

−2.40 −4.39, −0.41]

−3.77 −6.39, −1.15]

−3.52 −5.85, −1.19]

0.30 0.09, 0.93]

0.19 0.01, 4.09]

Yangxue qingnao granule [25]

−4.90 −7.10, −2.70]

−2.11 −3.60, −0.62]

−3.55 −5.65, −1.45]

−1.20 −2.14, −0.26]

−4.76 −7.77, −1.75]

−2.68 −4.82, −0.54]

5.13 0.24, 108.51]

0.37 0.15, 0.94]

Qin dan capsule [19]

−4.61 −8.88, −0.34]

−0.34 −3.05, 2.37]

0.45 0.08, 2.65]

0.62 0.10, 4.00]

Songling Xuemaikang capsule [21]

−6.10 −9.73, −2.47]

−9.80 −12.62, −6.98]

() Chinese medicine combined with conventional therapy versus placebo combined with the same conventional therapy

Qing xuan granule [29]

−1.15 −6.17, 3.87]

−2.24 −6.66, 2.18]

−0.91 −6.33, 4.51]

−2.11 −6.76, 2.54]

0.53 −4.83, 5.89]

−1.69 −5.92, 2.54]

0.51 0.18, 1.44]

−34.07 −55.89, −12.25]

AE: antihypertensive effect.
NSBPDR: nighttime systolic blood pressure decreased rate.
NDBPDR: nighttime diastolic blood pressure decreased rate.
RARBPR: reversed abnormal rhythm of blood pressure rate.
NR: not reported, the article did not report any information about this item.
NO: not observed, the article reported that no adverse effects were observed in the studies.
Outcomes marked were MD; others were RR.