Effect of Compound Chuanxiong Capsule on Inflammatory Reaction and PI3K/Akt/NF-κB Signaling Pathway in Atherosclerosis

Figure 3

Effect of Compound Chuanxiong Capsule (CCC) on atherosclerotic plaque. (a) Hematoxylin and eosin (HE) staining showing the pathological morphology change of the atherosclerotic plaque in aorta of the ApoE^−/− mice after the treatment of CCC. 1: ApoE^−/− group; 2: ApoE^−/− + lipitor group; 3: ApoE^−/− + CCC low group; 4: ApoE^−/− + CCC high group. Scale bars = 200 μm, and the black arrow indicates the atherosclerotic plaque in aorta. (b) The statistical analysis of the corrected area of atherosclerotic plaque and extracellular lipids content in plaque of the ApoE^−/− mice after the treatment of CCC. versus ApoE^−/− group. (c) Van Gieson (VG) staining showing the pathological morphology change of content in atherosclerotic plaque in aorta of the ApoE^−/− mice after the treatment of CCC. 1: ApoE^−/− group; 2: ApoE^−/− + lipitor group; 3: ApoE^−/− + CCC low group; 4: ApoE^−/− + CCC high group. Scale bars = 200 μm, and the black arrow indicates the collagen content in plaque. (d) The statistical analysis of the corrected area of collagen in atherosclerotic plaque of the ApoE^−/− mice after the treatment of CCC. versus ApoE^−/− group (ApoE^−/−: ; ApoE^−/− + lipitor: ; ApoE^−/− + CCC low: ; ApoE^−/− + CCC high: ).

(a)

(b)

(c)

(d)