Effect of Sterols Isolated from Myrtillocactus geometrizans on Growth Inhibition of Colon and Breast Cancer Cells

Table 4

Effects of peniocerol and macdougallin on cell cycle distribution.

Compound	Cell cycle phase (%)
	HCT-15			MCF-7
	G1	S	G2/M	G1	S	G2/M
Control (DMSO)
24 h	49.82 ± 0.61	22.05 ± 0.14	28.72 ± 0.40	59.6 ± 0.78	15.61 ± 0.86	25.22 ± 0.36
Peniocerol (1)
40 μM
60 μM
Macdougallin (2)
40 μM
60 μM
Timidine
2 mM	82.18 ± 1.09	13.84 ± 1.76	4.45 ± 1.94	70.16 ± 1.50	17.34 ± 0.67	13.05 ± 1.24
Nocodazol
100 ng/mL	9.2 ± 0.85	17.59 ± 1.59	73.63 ± 2.51	3.90 ± 0.92	3.95 ± 1.80	92.21 ± 1.54

Values are expressed as mean + S.D. of three independent experiments, each made in triplicate. Untreated cells were used as a control. Significant difference with untreated group (). ^aSignificant difference with treated group at 24 h ().