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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 591214, 8 pages
Research Article

Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome

1Postgraduate Program of Biotechnology, Ceará State University, Avenue Dr. Silas Munguba 1700, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil
2Course of Chemistry, Ceará State University, Avenue Dr. Silas Munguba 1700, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil
3Public Health Central Laboratory of Ceará, Avenue Barão de Sturdat 2405, 60120-002 Fortaleza, CE, Brazil
4Technological Development Park (PADETEC), Federal University of Ceará, Campus do Pici, 60455-970 Fortaleza, CE, Brazil
5Health Sciences Center, University of Fortaleza, Avenue Washington Soares 1321, 60811-905 Fortaleza, CE, Brazil

Received 1 April 2015; Revised 11 June 2015; Accepted 16 June 2015

Academic Editor: Orazio Taglialatela-Scafati

Copyright © 2015 Márcia Maria Mendes Marques et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Dengue represents a serious social and economic public health problem; then trying to contribute to improve its control, the objective of this research was to develop phytoterapics for dengue treatment using natural resources from Caatinga biome. Galactomannans isolated from Adenanthera pavonina L., Caesalpinia ferrea Mart., and Dimorphandra gardneriana Tull were chemically sulfated in order to evaluate the antioxidant, and antiviral activities and the role in the inhibition of virus DENV-2 in Vero cells. A positive correlation between the degree of sulfation, antioxidant and antiviral activities was observed. The sulfated galactomannans showed binding to the virus surface, indicating that they interact with DENV-2. The sulfated galactomannans from C. ferrea showed 96% inhibition of replication of DENV-2 followed by D. gardneriana (94%) and A. pavonina (77%) at 25 µg/mL and all sulfated galactomannans also showed antioxidant activity. This work is the first report of the antioxidant and antiviral effects of sulfated galactomannans against DENV-2. The results are very promising and suggest that these sulfated galactomannans from plants of Caatinga biome act in the early step of viral infection. Thus, sulfated galactomannans may act as an entry inhibitor of DENV-2.