Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Fig 4

Research Article

Toxic Markers of Matrine Determined Using 1H-NMR-Based Metabolomics in Cultured Cells In Vitro and Rats In Vivo

Figure 4

Multivariate statistical analysis based on 1H NMR spectra of HepG2 cells. PCA scores plots obtained from aqueous (a, c, and e) and lipophilic extracts (b, d, and f) of HepG2 cells following exposure to matrine for 12, 24, and 48 h, respectively. Representative S-plots of the OPLS-DA model derived from 1H-NMR data for aqueous (g) and lipophilic (h) extracts of HepG2 cells after the exposure to high dose matrine for 48 h. (●) control group, (▲) low dose group, (■) middle dose group, and (★) high dose group. Ala: alanine, Cho: choline, GSH: glutathione, Lac: lactate, pCho: phosphocholine, Tau: taurine, Chol: cholesterol, FA: fatty acid, and UFA: unsaturated fatty acid.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.