Figure 8: Silymarin improves liver regeneration. Silymarin accelerated cell cycle in liver regeneration after partial hepatectomy (PHx). Growth factors, HGF, TGFα, and TGFβ1, leading to the cell cycle running fast after silymarin treatment during liver regeneration. Silymarin makes the prolonged PHx cell cycle become normal. G1 phase check point protein: cyclin D1 and pRb. S phase check point protein: cyclin E and E2F. G2 phase check point protein: cyclin B, and M phase check point protein: cyclin A.