AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis

Figure 5

Effect of Pc-ME on LPS/D-GalN-induced hepatitis in mice. Mice were orally treated with Pc-ME (200 mg/kg) for six days before intraperitoneal injection of LPS/D-GalN. After 1 h, mice were sacrificed to collect blood samples and liver sections for biochemical parameter analysis of (a) ALT, (b) AST, and (c) histopathological examination. (d) Phospho- or total protein levels of MKK4, c-Fos, and β-actin in liver lysates were determined by immunoblot analysis.

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