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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 618409, 8 pages
http://dx.doi.org/10.1155/2015/618409
Research Article

Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from Camellia euphlebia Merr. ex Sealy in Mice

1School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China
2Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China
3Dalian SEM Bio-Engineering Technology Co. Ltd., Dalian 116620, China

Received 8 July 2015; Revised 14 August 2015; Accepted 16 August 2015

Academic Editor: David Mischoulon

Copyright © 2015 Dongye He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Camellia euphlebia Merr. ex Sealy is a traditional Chinese medicine that has been widely used for improvement of human emotions in the Guangxi Province of southern China. However, there are no studies about the anxiolytic and antidepressant activities of Camellia euphlebia. This study evaluated the anxiolytic and antidepressant activities of the aqueous extract from Camellia euphlebia (CEE) in mice. We found that administration of 400 mg/kg CEE or 20 mg/kg fluoxetine for 7 days significantly reduced the immobility time in both TST and FST. Oral administration of 100 mg/kg extract or 4 mg/kg diazepam for 7 days significantly increased the percentage of time spent and the number of entries into the open arms of the EPMT. In addition, the time spent by mice in the illuminated side of the LDBT was increased. Furthermore, pretreatment with 400 mg/kg CEE for 7 days significantly elevated the level of 5-HT and DA in the whole brain of mice. These results provide support for the potential anxiolytic and antidepressant activity of Camellia euphlebia and contribute towards validation of the traditional use of Camellia euphlebia in the treatment of emotional disorders.