In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism

Figure 3

The effects of Eurycoma longifolia extracts on metabolic activities of CYP1A2, CYP2A6, and CYP2C19 in recombinant CYP isozymes. Human recombinant CYP isozymes (CYP1A2, CYP2A6, and CYP2C19) were incubated with the corresponding specific substrate, NADPH-generating system, and Eurycoma longifolia extracts (- - -) for 30 min and the formation of the CYP-specific metabolite was plotted as the percentage of control.