Research Article
In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism
Table 1
Precursor-product ion pairs of CYP-specific metabolites for multiple reaction monitoring detection.
| | P450 isozyme | Metabolites monitored | Precursor ion | Product ion |
| | CYP 1A2 | Acetaminophen | 152.1 | 110.1 | | CYP 2A6 | 7-OH-coumarin | 162.9 | 106.9 | | CYP 2C8 | 6-OH-paclitaxel | 870.4 | 286.1 | | CYP 2C9 | 4-OH-diclofenac | 312.2 | 230.9 | | CYP 2C19 | 4-OH-mephenytoin | 235.0 | 150.1 | | CYP 2D6 | Dextrorphan | 258.3 | 157.1 | | CYP 3A4 |
1-OH-midazolam | 343.1 | 325.1 | | Internal standard | Terfenadine | 472.4 | 436.4 |
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