Research Article
Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol
Figure 5
Effect of ALL on in mouse ventricular myocytes. (a) Representative traces in mouse ventricular myocytes of the indicated three groups. Current amplitudes of with ISO treatment were significantly higher and were reduced by treatment with ALL (b). The concentration-dependent inhibition of ALL on is shown in (c), with IC50: 16.08 μM and Hill coefficient: 0.84. The current-voltage relationship demonstrated that current densities of from myocytes with ISO treatment were significantly larger than in control myocytes. The effect of ISO on was alleviated by 10 μM ALL treatment (d). , versus control myocytes; , versus myocytes with ISO treatment.
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