Acupuncture produces central activations in pain regions
Investigation of cerebral blood flow (CBF) changes after MA at ST36 (bil) and LU5 (bil) versus two nearby NAPs (bil)
Verum acupuncture but not sham acupuncture activated the left anterior cingulus, the insulae bilaterally, the cerebellum bilaterally, the left superior frontal gyrus, and the right medial and inferior frontal gyri.
A combined 11C diprenorphine PET study and fMRI study of acupuncture analgesia
Investigation of changes in binding of opioid agonists and changes of heat pain after MA versus Streitberger sham acupuncture at LI4 (r)
In comparison to Streitberger acupuncture, they observed significant changes during verum acupuncture in the medial and lateral pain networks, such as opioid-binding decreases (associated with greater endogenous opioid release) in the right OFC, left medial PFC, right insula, and right thalamus, as well as binding increases in the bilateral insula, right medial PFC/ACC, left OFC, and right brainstem. An overlap of results between fMRI signals and 11C diprenorphine blood pressure changes was only exhibited in the right medial OFC.
Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: A positron emission tomography study
Investigation of point specific CBF changes during MA at LI4 (r) versus nearby NAP
In comparison to acupuncture at a NAP, only MA at LI4 elicited activation of the regional CBF (rCBF) in the areas of the hypothalamus with extension to midbrain, the insula, the ACC, and the cerebellum. In addition, a further comparison of needling with deqi contrasted with minimal manipulation acupuncture and showed activation in the hypothalamus and the cerebellum. The activation by deqi in the hypothalamus extended to the midbrain/brain stem when contrasted with the brain at rest. Minimal stimulation activated neither the hypothalamus nor the insula when compared with rest situation.
A cerebral functional imaging study by positron emission tomography in healthy volunteers receiving true or sham acupuncture needling
Investigation of CBF changes during MA versus Streitberger needle versus overt blunt needling at TH5 (r)
For MA in comparison with overt blunt needling, more brain areas (BA7, 13, 18, 19, 21, 22, 27, 38, 40, 42, and 45) were activated, whereas, in comparison with Streitberger-like sham acupuncture, slightly less MA activation was found in the areas of BA13 and 42. During Streitberger-like sham acupuncture the areas BA4, 6, 7, 19, 22, and 41 showed activation.
Acupuncture of LI-4 in anesthetized healthy humans decreases cerebral blood flow in the putamen measured with positron emission tomography
Investigation of CBF changes during MA at LI4 (r) versus nearby NAP in anesthetized participants
Their results showed a decrease in CBF in the right medial frontal gyrus and in the left putamen for verum acupuncture. Acupuncture at a nearby NAP only caused a decrease of CBF in the right medial frontal gyrus.
We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.