Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-Activated Protein Kinase In Vitro and In Vivo

Figure 6

BHJRST treatment of db/db mice stimulates AMPK phosphorylation and reduces liver lipid accumulation. Animals (5 per group) were given BHJRST or double-distilled water () twice daily by gavage for 6 weeks; then, they were euthanized for analysis of liver tissues and serum, as described in Section 2. (a) Representative immunoblots of liver for phosphorylation for AMPK and ACC, total AMPK and ACC, and tubulin. (b) Densitometric analysis of phosphorylation of AMPK and ACC levels. The results are the mean ± SD for the intensity of the phosphorylated band divided by that for the “total” band expressed as a fold value of the control value. (c) Serum triglyceride and cholesterol levels. The data represent the mean ± SD. (d) Hepatic triglyceride, cholesterol, and total lipid levels. The data represent the mean ± SD. In (b–d), the value compared to the control group is shown either as a value or as .

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