Review Article

Analysis and Thoughts about the Negative Results of International Clinical Trials on Acupuncture

Table 2

Features of the studies.

NumberTitleDiseaseIntervention of the observation groupIntervention of the control groupSample sizeOutcomeFollow-up phase

001“The Effectiveness of Moxibustion for the Treatment of Functional Constipation: A Randomized, Sham-Controlled, Patient Blinded, Pilot Clinical Trial”ConstipationMoxibustionHeat insulation moxa-moxibustion (place a heat insulator under the true moxa-moxibustion)26Invalid2 weeks
002“The efficacy of Acupressure at the Sanyinjiao Point in the Improvement of Women’s General Health”Woman healthAcupressure at SP 6Sham acupuncture86Both valid, the real is the betterNo mention
003“Preliminary Research Article Electroacupuncture Is Not Effective in Chronic
Painful Neuropathies”
Chronic neuralgiaElectroacupuncture for 12 weeksPress the nonacupoint (not touch the tendo calcaneus in any meridian vessel on the back of leg)16InvalidNo mention
004“Feeding, Stooling and Sleeping Pattern in Infants with Colic- A Randomized Controlled Trial of Minimal Acupuncture”Infantile colicAcupunctureBlank90The symptoms improved, but no statistical differenceNo mention
005“The Effect of Acupuncture on Psychosocial Outcomes for Women Experiencing Infertility: A Pilot Randomized Controlled Trial”Women experiencing infertilityAcupunctureNo intervention32ValidNo mention
006“Effect of Acupuncture on Nausea and/or Vomiting during and after Cesarean Section in Comparison with Ondansetron”Nausea and vomiting when deliveryWrist band stimulative to acupointWrist band nonstimulative to PC 6450InvalidNo mention
007“Acupuncture in Children and Adolescents with Bronchial Asthma: A Randomised Controlled Study”Bronchial asthmaAcupunctureConventional treatment of western medicine93Partial response4 months
008“True and Sham Acupuncture Produced Similar Frequency of Ovulation and Improved LH to FSH Ratios in Women with Polycystic Ovary Syndrome”Polycystic ovarian syndromeElectroacupunctureStick on the skin by sham needle tubing and adjust the current to 096Both valid3 months
009“Effects of Auricular Acupuncture on Anthropometric, Lipid Profile, Inflammatory and Immunologic Markers: A Randomized Controlled Trial Study”ObesityAuricular acupunctureSham auricular acupuncture204ValidNo mention
010“Acupuncture for “Frequent Attenders” with
Medically Unexplained Symptoms:
A Randomised Controlled Trial (CACTUS Study)”
NeurosisAcupunctureConventional treatment80Valid52 weeks
011“The Effects of Acupuncture on the Inner Ear Originated Tinnitus”Inner ear originated tinnitusAcupunctureSham acupuncture (the Park sham acupuncture instrument)63Someone has valid in a short timeNo mention
012“Evaluation of Wet-Cupping Therapy for Persistent
Non-Specific Low Back Pain: A Randomised,
Waiting-List Controlled, Open-Label, Parallel-Group
Pilot Trial”
Persistent
nonspecific low back pain
Wet-cupping + excise + analgesic-antipyreticExcise + analgesic-antipyretic32Valid2 weeks
013“Acupuncture in Preterm Babies during Minor Painful Procedures”AcupunctureAcupunctureWithout any measure10ValidNo mention
014“Moxibustion for Cephalic Version: A Feasibility Randomised Controlled Trial”MalpositionMoxibustionWithout any measure20InvalidNo mention
015“Patient Education Integrated with Acupuncture for Relief of Cancer-Related Fatigue Randomized Controlled Feasibility Study”Cancer-related fatiguePatient education integrated with acupunctureSelf-management13ValidNo mention
016“Effectiveness of Acupressure and Acustimulation in Minimizing
Driving Simulation Adaptation Syndrome”
Minimizing
driving simulation adaptation syndrome
Acupressure and acustimulationSham wristband stimulation25ValidNo mention
017“Comparative Effects of Acupressure at Local and Distal Acupuncture Points on Pain Conditions and Autonomic Function in Females with Chronic Neck Pain”Chronic neck painAcupuncture at local pointsAcupuncture at distal points and blank control33Valid and the local points intervention is betterNo
018“Electroacupuncture for Cervical Ripening Prior to Labor Induction: A Randomized Clinical Trial”Cervical ripening prior to labor inductionElectroacupunctureMoxibustion72ValidNo mention
019“Effects of Acupuncture in Reducing Attrition and Mortality in HIV-Infected Men with Peripheral Neuropathy”HIV-infected men with peripheral neuropathyAcupunctureSham acupuncture114Valid in relieve of the pain and the mortality reduction, but the severe is not better than sham acupuncture14 weeks
020“Acupuncture Versus Paroxetine for the Treatment of Premature Ejaculation: A Randomized, Placebo-Controlled Clinical Trial”Premature ejaculationAcupunctureParoxetine90ValidNo
021“Ear Acupuncture in the Treatment of Migraine Attacks: A Randomized Trial on the Efficacy of Appropriate Versus Inappropriate Acupoints”Migraine attacksAcupuncture on auricular pointAcupuncture on inappropriate auricular point94Valid120 minutes
022“Cost-Effectiveness of Acupuncture Care as an Adjunct to Exercise-Based Physical Therapy for Osteoarthritis of the Knee”Osteoarthritis of the kneeAcupuncture care as an adjunct to exercise-based physical therapyEducation and excise352Valid12 months
023“A Randomised, Double-Blinded, Placebo-Controlled Study of Acupressure Wristbands for the Prevention of Nausea and Vomiting During Labour and Delivery”Nausea and vomiting when deliveryWrist band stimulative to acupointWrist band nonstimulative to PC 6340InvalidNo mention
024“Effect of Acupuncture on Allergen-Induced Basophil
Activation in Patients with Atopic Eczema: A Pilot Trial”
Atopic eczemaAcupunctureBlank10ValidNo mention
025“Acupuncture to Treat Primary Dysmenorrhea in Women: A Randomized Controlled Trial”Primary dysmenorrheaAcupunctureSham acupuncture (2–4 cm beside acupoints and Streitberger sham acupuncture)92Valid1 year
026“Getting the Grip on Nonspecific Treatment Effects: Emesis in Patients Randomized to Acupuncture or Sham Compared to Patients Receiving Standard Care”EmesisAcupunctureSham acupuncture (2 cm beside acupoints and park sham acupuncture)277Both better than conventional therapyNo mention
027“Perioperative Acupuncture and Postoperative Acupressure Can Prevent Postoperative Vomiting following Paediatric Tonsillectomy or Adenoidectomy: A Pragmatic Randomised Controlled Trial”Postoperative vomitingAcupuncture + conventional therapyConventional therapy154ValidYes
028“The Effect of Acupuncture on Postmenopausal Symptoms and Reproductive Hormones: A Sham Controlled Clinical Trial”Postmenopausal symptoms and reproductive hormonesAcupunctureSham acupuncture (the Streitberger sham acupuncture instrument)55ValidNo
029“Efficacy of Acupuncture in Preventing Atrial Fibrillation Recurrences after Electrical Cardioversion”Atrial fibrillationAcupunctureSham acupuncture54Valid12 months
030“Acupuncture for the Induction of Labour: A Double-Blind Randomised Controlled Study”AccouchingAcupunctureSham acupuncture (the Park sham acupuncture instrument)125InvalidYes
031“Comparison between the Effects of Trigger Point Mesotherapy Versus Acupuncture Points Mesotherapy in the Treatment of Chronic Low Back Pain: A Short Term Randomized Controlled Trial”Lumbago and backacheLidocaine injection at acupointLidocaine injection at trigger point62The trigger point mesoderm has good effect12 weeks
032“Relaxation Acupressure Reduces Persistent Cancer-Related Fatigue”Cancer-related fatigueRelaxation acupressureHigh frequency of acupuncture and low frequency of acupuncture43Relaxation acupressure validNo mention
033“Delayed Effect of Acupuncture Treatment in OA of the Knee: A Blinded, Randomized, Controlled Trial”OA of the kneeAcupuncture and conventional therapySham acupuncture and conventional therapy55ValidOne month