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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 672891, 10 pages
http://dx.doi.org/10.1155/2015/672891
Research Article

Danggui Buxue Tang Inhibits 2,4-Dinitrochlorobenzene: Induced Atopic Dermatitis in Mice

1Department of Nutrition, I-Shou University, Yanchao District, Kaohsiung City, Taiwan
2Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan
3Nutritional Science Department, Fu Jen Catholic University, New Taipei City, Taiwan
4Graduate Institute of Biotechnology, Chinese Culture University, Yang-Ming-Shan, Taipei, Taiwan
5Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan
6Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan
7Department of Nursing, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan
8Center for General Education, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan

Received 1 January 2015; Accepted 19 February 2015

Academic Editor: Xiu-Min Li

Copyright © 2015 Li-Wen Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Danggui Buxue Tang (DBT) is a herbal decoction that has been used in Chinese medicine to enhance qi and blood circulation. Previously, we found that DBT can suppress allergy-related asthma in mice, leading us to hypothesize that DBT might ameliorate allergy disease. In this study, we evaluated whether DBT can attenuate atopic dermatitis (AD) symptoms and have an anti-inflammatory effect on AD-like mice. The dorsal skin of female mice was shaved and sensitized cutaneously (skin smear) with 1-chloro-2,4-dinitrobenzene. Mice were then given various doses of DBT from days 14 to 29 cutaneously. DBT treatment suppressed ear swelling and skin inflammation and decreased mast cell and eosinophil infiltration into skin and ear tissue. DBT also inhibited levels of IgE and Th2-associated cytokine levels in serum. These results demonstrate that cutaneous administration of DBT reduced the development of AD-like skin lesions in mice.