Integrated Treatment of Aqueous Extract of Solanum nigrum-Potentiated Cisplatin- and Doxorubicin-Induced Cytotoxicity in Human Hepatocellular Carcinoma Cells

Figure 3

AE-SN-potentiated cisplatin and doxorubicin induced cytotoxicity in Hep3B and HepJ5 cells but had no effect on normal human pulmonary fibroblasts (WI-38 cells). (a–c) Cells were treated with 0 to 20 μM cisplatin and 0, 0.5, or 1.0 mg/mL of AE-SN for 48 h. (d–f) Cells were treated with 0 to 10 μM doxorubicin and 0, 0.5, or 1.0 mg/mL of AE-SN for 48 h. The cell viability was determined using an MTT assay; the data are presented as the mean ± standard deviation.

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