Research Article
Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)
Table 4
Pharmacokinetic parameters after oral (500 mg/kg) and i.v. administration (10 mg/kg) of curcumin to STZ-diabetic rats. Values are expressed as means ± SEM ().
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: elimination constant; half-life: time half-life; : area under plasma concentration/time plot until the last quantifiable value; : area under plasma concentration/time plot extrapolated to infinity; Cl: clearance; : volume of distribution; MRT: average mean residence time; : absorption constant; : maximum concentration; : time to reach ; : bioavailability. |