Chinese Herbal Medicine for Myelosuppression Induced by Chemotherapy or Radiotherapy: A Systematic Review of Randomized Controlled Trials

Table 1

Details of the included studies.

Author, year	Study types	Participants	Sample size (T/C)	Intervention	Outcome	Baseline treatment	Detail content of CHM	Lost to follow-up
Zhuang et al., 2009 [32]	Randomized, double-blind	Breast/nasopharyngeal/colon/lung	55/50	Extract of CHM versus placebo	PLT, RBC, and Hb	Chemotherapy or radiotherapy	G. lucidum extract, C. pilosula extract, A. sinensis extract, and citronellol powder were mixed into a capsule	16 incomplete, 7 giving up, 1 and poor compliance
Zhuang et al.,; 2012 [33]	Randomized, double-blind	Breast cancer	31/27	Extract of CHM versus placebo	PLT, RBC, and Hb	Chemotherapy or radiotherapy	A.sinensis extract, C. pilosula extract, G. tsugae extract, rose geranium power were mixed into a capsule. Liquid extracts were obtained following extraction with boiling water for 1 h. The extracts were freeze-dried	6 therapeutic regimen changed, 1 erythra, and 1 intolerance in capsules taste
Chen and Shen,; 2012 [37]	Randomized	Colon/rectal cancer	60/60	CHM plus chemotherapy versus chemotherapy	WBC, PLT, RBC, and Hb	Chemotherapy	Qisheng Mixture (Astragalus, angelica, Cimicifuga rhizome, and Rhizoma Polygoni Cuspidati); decocted with water into 300 mL	Not described
Xu et al.,; 2001 [39]	Randomized	Lung/breast/gastric/intestinal cancer	55/57	CHM plus chemotherapy versus chemotherapy	WBC	Chemotherapy	Shuanghuang Shengbai Granule; (Astragalus, polygonatum, Glossy privet fruit, Radix trichosanthis, Rhizoma Drynariae, etc.); processed into granules, 15 g per pack	Not described
Li et al.,; 2012 [38]	Randomized, double-blind	Refractory acute leukemia	118/117	CHM plus chemotherapy versus chemotherapy	WBC, PLT, and Hb	Chemotherapy	Compound Zhebei granules.; The preparation method was unknown	Not described
Shi et al.,; 2007 [34]	Randomized	Neuroblastoma tumors, nephroblastoma, and hepatoblastoma	30/30	CHM plus chemotherapy versus chemotherapy	WBC, PLT, and Hb	Chemotherapy	(1) Millet sprout, rice sprout, Qu Jian, Alpinia katsumadai, Costas, Amomum villosum.; (2) Fresh reed rhizome, fresh couchgrass root, Rehmanniae, Cortex Moutan, Agrimony, Platycladus orientalis carbon, and Clematis root; decocted with water twice	Not described
Chu,; 2007 [35]	Randomized	Lung/breast/gastric/colorectal/esophageal/pancreatic	36/36	CHM plus chemotherapy versus chemotherapy	WBC, PLT, and Hb	Chemotherapy	Bushen Shengxue recipe; (Radix rehmanniae, Astragalus root, Angelica, and Radix Polygoni Multiflori); decocted with water	Not described
Liu,; 2013 [36]	Randomized	Lung/breast/stomach/prostate	28/28	CHM plus chemotherapy versus chemotherapy	WBC	Chemotherapy	Licorice root, deerhorn glue, Radix Rehmanniae Preparata, Fructus Psoraleae, Himalayan teasel root, Poria, Atractylodes, Radix Pseudostellariae, Angelica, and Astragalus sunburn; decocted with water three times into 300 ml	Not described