Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network

Figure 1

Curcumin blocked glutamate-mediated calcium influx and blocked the translocation of AKAP79-PKA complex. (a) Summary data describing the change of . (b) Glutamate induced an increase of AKAP79 in the S2 cytosolic fraction accompanied by decrease of AKAP79 in the P2 membrane fraction, which was blocked by curcumin. For membrane protein detection, commonly used internal reference protein is --ATPase. (c, d) Western blotting bands were quantified using Image J software. versus glutamate group. ().

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