Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network
The neuroprotection of curcumin was abolished by PKA anchoring inhibitor Ht31. (a) Western blot analysis of the phosphorylations of AKT, MEK1/2, ERK1/2, and CREB. (b–e) Western blotting bands were quantified using Image J software. (f) Pretreatment with Ht31 suppressed curcumin-mediated increase of cell viability against glutamate insult. (g) LDH assay further confirmed the connection between PKA anchoring and curcumin-mediated neuroprotective effects. , , and versus curcumin group (b–e) and versus control values (f, g). ().
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