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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 706782, 10 pages
Research Article

The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/KATP Signaling Pathway

1Departamento de Fisiologia e Farmacologia, UFC, Coronel Nunes de Melo 1127, Rodolfo Teófilo, 60430-270 Fortaleza, CE, Brazil
2Centro Universitário Estácio do Ceará, Via Corpvs, Rua Eliseu Uchoa Becco, No. 600, Bairro Água Fria, 60810-270 Fortaleza, CE, Brazil
3Departamento de Bioquímica e Biologia Molecular, UFC, Campus do Pici, Caixa Postal 6033, 60451-970 Fortaleza, CE, Brazil

Received 3 July 2015; Revised 26 October 2015; Accepted 26 November 2015

Academic Editor: Guillermo Schmeda-Hirschmann

Copyright © 2015 Nylane Maria Nunes de Alencar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Plumeria rubra (Apocynaceae) is frequently used in folk medicine for the treatment of gastrointestinal disorders, hepatitis, and tracheitis, among other infirmities. The aim of this study was to investigate the gastroprotective potential of a protein fraction isolated from the latex of Plumeria rubra (PrLP) against ethanol-induced gastric lesions and describe the underlying mechanisms. In a dose-dependent manner, the pretreatment with PrLP prevented ethanol-induced gastric lesions in mice after single intravenous administration. The gastroprotective mechanism of PrLP was associated with the involvement of prostaglandins and balance of oxidant/antioxidant factors. Secondarily, the NO/cGMP/ pathway and activation of capsaicin-sensitive primary afferents were also demonstrated as part of the mechanism. This study shows that proteins extracted from the latex of P. rubra prevent gastric lesions induced in experimental animals. Also, the results support the use of the plant in folk medicine.